Just allowing players to go heavy on the difficulty settings can already help a lot of people to play through a game regardless of accessibility requirements.
It’s relevant to consider that if these options should actively help to make to game more accessible extreme options like reducing damage to the player to 0, being undetectable during stealth encounters and increasing how much damage the player can deal should be considered and are encouraged.
In general, the more settings with as drastic as possible ranges for the settings effect the more accessibility needs will be met by them.
List of potential settings:
- Player damage received
- Player damage dealt
- Enemy attention radius for stealth encounter
- Enemy alert speed for stealth encounter
- Shop prices
- Mana/Ammo recovery speed/use amount/reserves
- IFrames amount
- Stamina use rate/recovery
- Cooldowns duration
- Pause during menus/quick menus
- Enemy reinforcement amount
- Enemy highlighting
- Enemy aggression
- Unlock abilities/weapons early
- Starting equipment
- Lose resources on death
- Quest and mission marker frequency
- Friendly fire/selfe damage
- Inventory/storage limits
- Additional UI information like enemies on minimap or upkeep costs which would usually be hidden
- Vehicle handling
- Vehicle damage on/off/off for player vehicle
- Map complexity
- Reward amount
- Hints
- Trap frequency
Additional Reading
https://www.dualshockers.com/dishonored-2-custom-difficulty-settings/
